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Sequencing Solutions

Genome-wide detection and phasing of genetic and epigenetic variants from a single library prep- Two Features at One Go

HiFi PacBio Sequencing is not limited to characterizing the genome. It simultaneously measures the epigenome by detecting a fifth base — 5mC at CpG sites.
  • Detects distinct regional epigenetic patterns
  • Accesses methylation in the full genome
  • Identifies allele-specific methylation
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Whole Genome Sequencing

Gain an unbiased, base-by-base view of the entire genome. WGS detects single nucleotide variants, insertions /deletions, copy number variations (CNVs) and structural variants. It’s widely used in population genetics, rare disease research, evolutionary studies, and complex trait mapping.

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Whole Exome Sequencing (WES)

Focus on the protein-coding regions that account for ~1–2% of the genome but harbor ~85% of disease-causing mutations. WES is a cost-effective strategy for identifying pathogenic variants, especially in clinical diagnostics and hereditary disease research.

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Metagenomics

The study of genetic material recovered directly from environmental samples, such as soil, water, or the human microbiome, without the need for culturing individual organisms. Unlike traditional genomics, which focuses on a single organism’s DNA, metagenomics provides a comprehensive view of entire microbial communities

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Sanger Sequencing

Sanger Sequencing is a classical method of DNA sequencing developed by Frederick Sanger in 1977. It is also known as the chain-termination method and is widely used for accurate, small-scale DNA sequencing (e.g., verifying cloned DNA, detecting mutations, sequencing plasmids or PCR products).

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Single-cell Sequencing

Dissect cellular heterogeneity by profiling gene expression in thousands of individual cells. Ideal for understanding tissue composition, immune landscapes, stem cell differentiation, or tumor microenvironments. Supports droplet-based and plate-based protocols.

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Epigenomics

Epigenomics is the study of the chemical changes to DNA and histones that regulate gene activity without altering the underlying genetic sequence. These changes, such as DNA methylation and histone modification, can influence gene expression, impacting cellular processes like development, aging, and disease. Epigenetic marks can be passed down to offspring, affecting inheritance and evolution, and are influenced by environmental factors, lifestyle, and external stresses.

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Spatial Sequencing

Spatial sequencing bridges the gap between single-cell genomics and tissue context by preserving the physical location of cells while analyzing their molecular profiles. This cutting-edge technique combines high-resolution imaging with NGS or in situ sequencing to reveal how gene expression varies across tissue microenvironments—critical for understanding tumor heterogeneity, immune cell interactions, and developmental biology.

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RNA Sequencing

Unlock transcriptomic data to study gene expression, differential expression, and alternative splicing. RNA-Seq enables comprehensive insights into coding and non-coding RNAs, revealing functional elements of the genome and offering a dynamic view of cellular states across conditions or tissues.

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Pre-Med Library Sequencing

Pre-Med Library Sequencing refers to targeted sequencing of a curated panel of genes known to be associated with a broad range of inherited conditions and actionable clinical outcomes. Designed for preventive healthcare, this approach enables early detection of genetic variants linked to conditions such as cancer, cardiovascular disorders, neurological diseases, and pharmacogenomic responses.

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Isolation of DNA/RNA

Isolation of DNA/RNA is a fundamental step in molecular biology, enabling the extraction of high-quality genetic material from biological samples such as blood, tissues, or cells. Accurate and efficient isolation is critical for downstream applications including sequencing, PCR, gene expression analysis, and diagnostic testing.

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Whole Genome sequencing

Whole-genome sequencing (WGS) is a powerful technique that decodes the complete DNA of an organism. It plays a key role in identifying genetic disorders, cancer mutations, and tracking disease outbreaks. Thanks to advances in next-generation sequencing (NGS), WGS is now faster and more affordable, making it useful not only for human genomes but also for studying plants, animals, and microbes in agriculture and research.

Short-Read Sequencing
Short-read sequencing is the workhorse of modern genomics. It delivers high-throughput, accurate data at a low cost, enabling essential applications like variant discovery, transcriptomics, and targeted amplicon sequencing.
Long-Read Sequencing
Long-read sequencing (e.g., PacBio HiFi) generates ultra-long, accurate reads that resolve complex genomic regions, full-length transcripts, and structural variations. It enables:
  • Telomere-to-telomere genome assemblies
  • Accurate isoform detection (Iso-Seq)
  • Direct epigenetic detection
  • Strain-level microbiome analysis

    LRS is transforming rare disease diagnosis, cancer genomics, and functional annotation by providing a more complete view of the genome and transcriptome.

    • Whole Exome Sequencing

    Whole exome sequencing (WES) focuses on the protein-coding regions of the genome, where most disease-related mutations occur. It’s a cost-effective method for identifying potential genetic causes of disease. In addition, techniques like copy number variation (CNV) and structural variant (SV) analysis help detect genomic alterations that affect gene expression, offering deeper insights into the genetic basis of various disorders.

    Metagenomics

    The study of genetic material recovered directly from environmental samples, such as soil, water, or the human microbiome, without the need for culturing individual organisms. Unlike traditional genomics, which focuses on a single organism’s DNA, metagenomics provides a comprehensive view of entire microbial communities, revealing their diversity, functions, and interactions.

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    Whole Metagenome Sequencing
    Whole Metagenome Sequencing (WMS) is an advanced genomic technique that analyzes all the genetic material (DNA/RNA) present in a complex environmental or biological sample—without the need for culturing individual microbes. Unlike 16S rRNA or ITS sequencing (which target specific marker genes), WMS provides a comprehensive view of microbial diversity, functional potential, and interactions within a community.
    16s Sequencing
    16S rRNA sequencing is a cost-effective method for profiling bacterial and archaeal communities by targeting a conserved genetic marker. It enables taxonomic classification and comparison of microbial diversity across samples—such as from the gut or environment—but does not resolve species or functional genes. Ideal for large-scale surveys of microbiome composition.
    ITS Sequencing
    ITS sequencing targets variable genomic regions to provide precise fungal and eukaryotic identification. It is widely used to study diversity in environmental, clinical, and industrial samples—offering species-level resolution where 16S falls short. A gold standard for detecting fungi, molds, and protists in microbiome research.

    Single Cell Sequencing

    Single-cell sequencing analyzes the genetic material of individual cells, uncovering hidden diversity missed by bulk methods. It helps identify rare cell types, trace development, and reveal disease mechanisms, advancing fields like cancer research, neurobiology, and immunotherapy.

    Epigenomics

    Epigenomics is the study of the chemical changes to DNA and histones that regulate gene activity without altering the underlying genetic sequence. These changes, such as DNA methylation and histone modification, can influence gene expression, impacting cellular processes like development, aging, and disease. Epigenetic marks can be passed down to offspring, affecting inheritance and evolution, and are influenced by environmental factors, lifestyle, and external stresses.

    Methylation Sequencing
    Methylation sequencing, also known as DNA methylation sequencing, is a technique used to map the DNA methylation patterns across the genome. Methylation typically occurs at cytosine residues in CpG dinucleotides, where a methyl group is added to the DNA molecule, impacting gene expression.
    ChIP Sequencing
    ChIP-sequencing (Chromatin Immunoprecipitation Sequencing) is a powerful technique used to analyze protein-DNA interactions and study the epigenome. It combines chromatin immunoprecipitation (ChIP) with next-generation sequencing (NGS) to identify binding sites of DNA-associated proteins (like transcription factors, histones, or other chromatin modifiers) across the entire genome.

    Spatial Sequencing

    Spatial sequencing links genomic data to the exact location of cells within tissues, combining high-resolution imaging with sequencing to map gene expression in context. This approach reveals how cells interact within their microenvironment, helping to understand tumor diversity, immune responses, and development. By preserving spatial information, researchers can identify unique biomarkers and cell communication patterns that bulk or single-cell methods miss.

    RNA Sequencing

    RNA-Seq (RNA sequencing) is a high-throughput sequencing technique used to analyze the transcriptome, which is the complete set of RNA molecules transcribed in a cell. It allows for the comprehensive study of gene expression, alternative splicing, and other RNA-related phenomena.

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    Whole Transcriptome Sequencing (WTS)
    Whole Transcriptome Sequencing (WT-Seq) captures the complete set of RNA transcripts in a cell, providing a comprehensive view of gene expression, alternative splicing, and non-coding RNA activity. It is essential for gaining a nuanced understanding of cellular function in disease, development, and basic biology.
    Small RNA Sequencing
    Small RNA sequencing (small RNA-seq) is a high-throughput technique used to identify and quantify small RNA molecules in a biological sample. These small RNAs are typically 18–40 nucleotides long.
    Metatranscriptomics
    Metatranscriptomics analyzes the entire RNA of microbial communities to reveal their actively expressed genes and real-time functional activity. This approach shows how microbes respond to their environment, illuminating key processes in health, disease, and ecology.
    Iso Sequencing
    Iso-Seq leverages PacBio long-read sequencing to sequence complete RNA transcripts without assembly. This provides unbiased, precise discovery of alternative splicing, novel isoforms, and fusion genes, offering a comprehensive view of isoform diversity for advanced research in cancer, neuroscience, and development.

    LibSeq

    Have libraries already prepared for various seqeuncing applications? Submit your pre-made libraries for rapid sequencing. We perform essential quality checks, process your samples, and deliver the results as raw data or with comprehensive bioinformatic analysis.

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    Isolation of DNA\RNA

    We deliver high-throughput, automated nucleic acid extraction services, providing high-quality DNA and RNA from any sample type to accelerate your research.

    Sanger Sequencing

    Sanger Sequencing is a classical method of DNA sequencing developed by Frederick Sanger in 1977. It is also known as the chain-termination method and is widely used for accurate, small-scale DNA sequencing (e.g., verifying cloned DNA, detecting mutations, sequencing plasmids or PCR products).